Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.

Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We have examined peptides derived from the TRIF TIR domain for ability to inhibit TLR4. In addition to a previously identified BB loop peptide (TF4), a peptide der...

Regulated by ADAM 15 TRIF - Mediated TLR 3 and TLR 4 Signaling Is Shevlin

Regulated by ADAM 15 TRIF - Mediated TLR 3 and TLR 4 Signaling Is

Negatively Regulated by ADAM 15 TRIF - Mediated TLR 3 and TLR 4 Signaling Is

TLR4 Signaling via MyD88 and TRIF